Comparison of Serologic Diagnosis of Taeniosis and Cysticercosis in Field Samples from Eastern Zambia
AbstractBackground: Neurocysticercosis is a leading cause of epilepsy in Taenia solium endemic regions of the world accounting for about 30% of all epileptic cases. The main aim of this study was to do a Comparison of Serologic Diagnosis of Taeniosis and Cysticercosis in Field Samples from Eastern Zambia. Methods: Retrospectively collected Samples through community-based cross sectional and longitudinal studies which looked at the prevalence and incidence of human T. solium infections, respectively, and described in earlier reports were selected for this laboratory based study. Samples, with coproantigen ELISA and serum antigen ELISA which the results were known were randomly selected for this study. Results: A total of 886 serum samples were analyzed. The rT24 /rES33 EITB detected a taeniosis and cysticercosis prevalence of 5.9% and 9.5%, respectively. On performance the Kappa statistics revealed a fair agreement of rT4/rES33 EITB (Kappa value of 0.2781- 0.2117) compared to coproantigen ELISA and serum antigen ELISA. Although there is not a good agreement between the antibody and antigen test. Conclusion: This study found that the performance of rT4/rES33 EITB compared to coproantigen ELISA and serum antigen ELISA were fair and because the agreement was not good between the antibody and antigen test the, selection of a test must be carefully made, with consideration of what is needed.
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