Identification of MHC Alleles Associated with Disease Resistance/Susceptibility in Smallholder Cattle in Zambia

  • Isaac Kombe Silwamba Livestock Laboratory, Department of Technical Services, Livestock Services Cooperative Society, Pamodzi Highway, Showgrounds, Lusaka, Zambia
  • Martin Simuunza Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia
  • King Nalubamba Department of Clinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia
  • Joseph Ndebe Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia
  • Edgar Simulundu Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia
  • Geoffrey Mainda Department of Veterinary Services, Ministry of Fisheries and Livestock, Lusaka, Zambia
  • John. Bwalya Muma Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia
Keywords: Major Histocompatibility Complex, Bovine Leukaemia Virus, Foot and Mouth Disease, Mastitis, Theileriosis

Abstract

The occurrence of Major Histocompatibility Complex (MHC) alleles associated with resistance to Mastitis, Bovine Leukaemia Virus (BLV), Theileriosis, Foot and Mouth Disease (FMD) and susceptibility Dermatophilosis in African cattle is ill defined. The researchers used manual annotation to screen for five MHC alleles previously known to be associated with resistance/susceptibility to these diseases from a database of alleles sequenced from 846 cattle in Zambia. Overall, the researchers found twenty-eight (3.3%), twenty-one (2.6%), fifty-five (6.5%), and fifteen (1.8%) animals with resistance alleles to Mastitis, BLV, Theileriosis, FMD; and thirty-nine (4.6%) animals with susceptibility alleles to Dermatophilosis, respectively. This study provides the first evidence of resistance/susceptibility alleles in smallholder cattle in Zambia and the data could aid strategies for breeding cattle with enhanced resistance to disease in endemic countries.

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Published
2021-05-11
How to Cite
1.
Silwamba I, Simuunza M, Nalubamba K, Ndebe J, Simulundu E, Mainda G, Muma J. Identification of MHC Alleles Associated with Disease Resistance/Susceptibility in Smallholder Cattle in Zambia. Journal of Agricultural and Biomedical Sciences [Internet]. 11May2021 [cited 6Jul.2025];5(1). Available from: https://journals.unza.zm/index.php/JABS/article/view/494
Section
Veterinary Medicine

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