Identification of MHC Alleles Associated With Disease Resistance/Susceptibility In Smallholder Cattle In Zambia
Keywords:
Major Histocompatibility complex; Bovine leukaemia virus (BLV); Foot and Mouth disease; Mastitis; Theileriosis
Abstract
Background: The occurrence of Major Histocompatibility complex (MHC) alleles associated with disease resistance/susceptibility in African cattle is ill-defined. Methods: Herein, we used manual annotation to identify animals possessing MHC alleles associated with disease resistance/susceptibility from a database of alleles sequenced from 846 cattle in Zambia. Results: Overall, we found 28 (3.3%), 21 (2.6%), 55 (6.5%), and 15 (1.8%) animals with resistance alleles to Mastitis, BLV, Theileriosis, FMD, and 39 (4.6%) animals susceptibility alleles to Dermatophilosis, respectively. Conclusion: This study provides the first evidence of resistance/susceptibility alleles in smallholder cattle in Zambia and the data could aid strategies for breeding cattle with enhanced resistance to disease in endemic countries.References
1. Lubungu M and Mofya R,. the Status of the Smallholder Livestock Sector in Zambia. 2012; Technical report.
2. Ministry of Fisheries and Livestock, Central Statistical Office; the 2017/2018 Livestock and Aquaculture Census. Summary report 2019; Lusaka Zambia.
3. Food and Agriculture Organization of the United Nations,. Economic analysis of animal diseases. Animal Production and Health Guidelines. No. 18. 2016; Rome Italy.
4. Oldenbroek K and Liesbeth van der W,. Textbook animal breeding Animal breeding and genetics for BSc students. Centre for Genetic Resources and Animal Breeding and Genomics Group. Wageningen University and Research Centre, 2014; the Netherlands. Groen Kennisnet. p. 46.
5. Vasoya D, Law A, Motta P, Yu M, Muwonge A, Cook E, et al., Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing, Immunogenetics. 2016; 68:765–781
6. Kulberg S, Heringstad B, Guttersrud O, Olsaker I,. Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows. Journal of Animal Breeding and Genetics 2007; 124 (4) 201–207.
7. Xu A, van Eijk MJ, Park C, and Lewin HA,. Polymorphism in BoLA‐DRB3 exon 2 correlates with resistance to persistent lymphocytosis caused by bovine leukaemia virus. Journal of Immunology 1993; 6977‐85.
8. Baxter R, Craigmile SC, Haley C, Douglas AJ, Williams JL, and Glass EJ,. BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle. Vaccine 2009; 28, 28–37.
9. Ballingall K, Luyai A, Rowlands S J, Musoke A, Morzaria S, and Mckeever D,. Bovine Leukocyte Antigen Major Histocompatibility Complex Class II DRB3*2703 and DRB3*1501 Alleles Are Associated with Variation in Levels of Protection against Theileria parva Challenge following Immunization with the Sporozoite p67 Antigen. Infection and immunity. 2004; 72. 2738-41.
10. Maillard JC, Chantal I, Berthier D, Stachurski F, and Elsen JM,. Molecular markers of genetic resistance and susceptibility to bovine dermatophilosis. Archives of Animal Breeding 1999; 42 93–96.
11. Samui KL and Hugh-Jones ME,. The prevalence of bovine dermatophilosis in zambia proceedings of the 5th International Symposium on Veterinary Epidemiology and Economics. Acta Veterinaria Scandinavia, 1988; Supplementum 84.
12. Phiri MM, Kaimoyo E, Changula K, Silwamba I, Chambaro HM, Kapila P, et al., Molecular detection and characterization of genotype 1 bovine leukemia virus from beef cattle in the traditional sector in Zambia. Archives of virology 2019; 04350-6
13. Nambota A, Samui K, Sugimoto C, Kakuta T, and Onuma M,. Theileriosis in Zambia. Aetiology, epidemiology and control measures. Japanese journal of veterinary research 1994; 42.1.1
14. Whitworth KM, Rowland RR, Petrovan V,. Resistance to coronavirus infection in amino peptidase N-deficient pigs. Transgenic Research; 2018; DOI: 10.1007/s11248-018-0100-3
15. World organisation for animal health,. Listed diseases, infections and infestations in force. 2019; https://www.oie.int/animal-health-in-the-world/oie-listed-diseases.
16. Food and Agriculture Organization of the United Nations,. Impact of mastitis in small scale dairy production systems. Animal Production and Health Working Paper. 2014; No. 13. Rome Italy.
17. Samui KL and Hugh-Jones ME,. The financial and production impacts of bovine dermatophilosis in Zambia. Veterinary Research Communications. 1990; (14) 357.
2. Ministry of Fisheries and Livestock, Central Statistical Office; the 2017/2018 Livestock and Aquaculture Census. Summary report 2019; Lusaka Zambia.
3. Food and Agriculture Organization of the United Nations,. Economic analysis of animal diseases. Animal Production and Health Guidelines. No. 18. 2016; Rome Italy.
4. Oldenbroek K and Liesbeth van der W,. Textbook animal breeding Animal breeding and genetics for BSc students. Centre for Genetic Resources and Animal Breeding and Genomics Group. Wageningen University and Research Centre, 2014; the Netherlands. Groen Kennisnet. p. 46.
5. Vasoya D, Law A, Motta P, Yu M, Muwonge A, Cook E, et al., Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing, Immunogenetics. 2016; 68:765–781
6. Kulberg S, Heringstad B, Guttersrud O, Olsaker I,. Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows. Journal of Animal Breeding and Genetics 2007; 124 (4) 201–207.
7. Xu A, van Eijk MJ, Park C, and Lewin HA,. Polymorphism in BoLA‐DRB3 exon 2 correlates with resistance to persistent lymphocytosis caused by bovine leukaemia virus. Journal of Immunology 1993; 6977‐85.
8. Baxter R, Craigmile SC, Haley C, Douglas AJ, Williams JL, and Glass EJ,. BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle. Vaccine 2009; 28, 28–37.
9. Ballingall K, Luyai A, Rowlands S J, Musoke A, Morzaria S, and Mckeever D,. Bovine Leukocyte Antigen Major Histocompatibility Complex Class II DRB3*2703 and DRB3*1501 Alleles Are Associated with Variation in Levels of Protection against Theileria parva Challenge following Immunization with the Sporozoite p67 Antigen. Infection and immunity. 2004; 72. 2738-41.
10. Maillard JC, Chantal I, Berthier D, Stachurski F, and Elsen JM,. Molecular markers of genetic resistance and susceptibility to bovine dermatophilosis. Archives of Animal Breeding 1999; 42 93–96.
11. Samui KL and Hugh-Jones ME,. The prevalence of bovine dermatophilosis in zambia proceedings of the 5th International Symposium on Veterinary Epidemiology and Economics. Acta Veterinaria Scandinavia, 1988; Supplementum 84.
12. Phiri MM, Kaimoyo E, Changula K, Silwamba I, Chambaro HM, Kapila P, et al., Molecular detection and characterization of genotype 1 bovine leukemia virus from beef cattle in the traditional sector in Zambia. Archives of virology 2019; 04350-6
13. Nambota A, Samui K, Sugimoto C, Kakuta T, and Onuma M,. Theileriosis in Zambia. Aetiology, epidemiology and control measures. Japanese journal of veterinary research 1994; 42.1.1
14. Whitworth KM, Rowland RR, Petrovan V,. Resistance to coronavirus infection in amino peptidase N-deficient pigs. Transgenic Research; 2018; DOI: 10.1007/s11248-018-0100-3
15. World organisation for animal health,. Listed diseases, infections and infestations in force. 2019; https://www.oie.int/animal-health-in-the-world/oie-listed-diseases.
16. Food and Agriculture Organization of the United Nations,. Impact of mastitis in small scale dairy production systems. Animal Production and Health Working Paper. 2014; No. 13. Rome Italy.
17. Samui KL and Hugh-Jones ME,. The financial and production impacts of bovine dermatophilosis in Zambia. Veterinary Research Communications. 1990; (14) 357.
Published
2021-05-11
How to Cite
1.
Silwamba I, Simuunza M, Nalubamba K, Ndebe J, Simulundu E, Mainda G, Muma J. Identification of MHC Alleles Associated With Disease Resistance/Susceptibility In Smallholder Cattle In Zambia. University of Zambia Journal of Agricultural and Biomedical Sciences [Internet]. 11May2021 [cited 28May2022];5(1). Available from: https://journals.unza.zm/index.php/JABS/article/view/494
Section
Veterinary Medicine